lincolnensis. Clindamycin hydrochloride has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Like all antibiotics, gastrointestinal upset (nausea, diarrhea, vomiting, or loss of appetite) is the leading side effect of clindamycin. Safety in gestating queens or breeding male cats has not been established. Oral: 5.0-15.0 mg/lb body weight every 12 hours. Possible adverse effects include: 1. Site and Mode of Action: Clindamycin is an inhibitor of protein synthesis in the bacterial cell. Duration: Treatment with ANTIROBE products may be continued up to a maximum of 28 days if clinical judgment indicates. Give this medication the entire length of time prescribed by your veterinarian. C. difficile colitis If you notice bloody stools contact your vet immediately for advice on how to proceed. What is clindamycin? Still, it is a Each mL of ANTIROBE AQUADROPS oral solution contains clindamycin hydrochloride equivalent to 25 mg clindamycin; and ethyl alcohol, 8.64%. The medicine is available in both tablets and in an oral similar in function and chemical composition to drugs like Some cats are allergic or hypersensitive to clindamycin. Antirobe has a few side effects. 150 mg Capsule, each white capsule contains clindamycin hydrochloride equivalent to 150 mg of clindamycin. help address and treat the infection. Common Name: Antirobe® Drug Type: Antibiotic, Anti-protozoal Used For: Bacterial infections Species: Dogs, Cats Administered: Oral liquid, 25mg tablets, 150mg capsules How Dispensed: Prescription only FDA Approved: Yes Safety in gestating bitches and queens or breeding male dogs and cats has not been established. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced antibiotic produced by Streptomyces lincolnensis var. Clindamycin can cause the following side-effects, so make sure to keep an eye out for them [5]: Dog Serum Levels: Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 2.5 mg/lb of clindamycin hydrochloride every 12 hours. Diarrhea 2. The minimum inhibitory concentrations (MICs) of Gram-positive and obligate anaerobic pathogens isolated from dogs and cats in the United States are presented in Table 1 and Table 2. Infections The site of binding appears to be in the 5OS sub-unit of the ribosome. Side Effects. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Infected Wounds, Abscesses, and Dental Infections. Side effects occasionally observed in either clinical trials or during clinical use were vomiting and diarrhea. Cat Serum Levels: Serum levels at or above 0.5 µg/mL can be maintained by oral dosing at a rate of 5 mg/lb of clindamycin hydrochloride oral solution every 24 hours. Ask your veterinarian whether this is appropriate for your pet. and effectively as possible. To report a suspected adverse reaction call 1-888-963-8471. It is a brand name of the drug that is used in both dogs and cats. Therefore, ANTIROBE should be used with caution in animals receiving such agents. Microbiology: Clindamycin is a lincosaminide antimicrobial agent with activity against a wide variety of aerobic and anaerobic bacterial pathogens. Clindamycin differs from cell wall inhibitors in that it causes irreversible modification of the protein-synthesizing subcellular elements at the ribosomal level. untreated, these bacteria can continue to spread and grow and may ANTIROBE 150 mg, administer 2-6 capsules every 12 hours for each 60 pounds of body weight. Antirobe capsules are used in the treatment of serious infections such as soft tissue infections, dental infections, and bone infections. ANTIROBE AQUADROPS, administer 2-6 mL/10 lbs body weight every 12 hours. Pain at injection site (when injecting IM) 5. Side effects occasionally observed in either clinical trials or during clinical use were vomiting and diarrhea. internal organs and other vital parts. Liver failure is irreversible. Dental infections due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. reaction to the medicine. Overall: Value For Money: Effectiveness: Ease Of Use: Absence Of Side Effects: 2 out of 2 (100 %) customers would recommend this product. Oral: 2.5-15.0 mg/lb body weight every 12 hours. are generally caused by bacteria of some type or another. Its use to treat certain infections, such as toxoplasmosis, is âoff labelâ or âextra-labelâ. Side Effects. ANTIROBE AQUADROPS oral solution (For Use in Dogs and Cats) is a palatable formulation intended for oral administration. prescription drug that requires a veterinarian's watchful care. is a particular type of antibiotic that targets bacteria that cause We comply with the HONcode standard for trustworthy health information -, Warnings and cautions for Antirobe Capsules, Direction and dosage information for Antirobe Capsules. Specific animal medications, consisting of some antibiotics, need to not be used in conjunction with clindamycin.Brand/generic equivalents: Antirobe, Antirobe Aquadrops, Cleocin, Dalacin, and Evoclin begin antirobe, as it can interact badly with certain types of medicine. ANTIROBE 150 mg, administer 1-6 capsules every 12 hours for each 60 pounds of body weight. It's still important, however, to continue to give him the medicine Oral Solution ANTIROBE AQUADROPS, administer 1-6 mL/10 lbs body weight every 12 hours. Additionally, the most common negative effects of antirobe in dogs will be dependent upon his weight, size, age, previous health Treatment of acute infections should not be continued for more than three or four days if no response to therapy is seen. ANTIROBE Capsules and ANTIROBE AQUADROPS oral solution contain clindamycin hydrochloride which is the hydrated salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced antibiotic produced by Streptomyces lincolnensis var. Rats administered clindamycin hydrochloride at 600 mg/kg/day (272.7 mg/lb/day) for six months tolerated the drug well; however, dogs orally dosed at 600 mg/kg/day (272.7 mg/lb/day) vomited, had anorexia, and subsequently lost weight. It is Antirobe Capsules are an oral antibiotic for dogs and cats. The exact amount of antirobe that you'll give to your pet antirobe. There was no bioactivity accumulation after a regimen of multiple oral doses in healthy dogs. throughout the full duration, as this will ensure that all of the Antirobe, Antirobe Aquadrops, Cleocin, Dalacin,and Evoclin. How Clindamycin Is Supplied Clindamycin is available in 25 mg, 75 mg and 150 mg capsules and a 25 mg/ml oral suspension. Antibiotics are medicines that destroy or inhibit the growth of Patients with very severe renal disease and/or very severe hepatic disease accompanied by severe metabolic aberrations should be dosed with caution, and serum clindamycin levels monitored during high-dose therapy. approved for use in humans as well. During the studies conducted prior to approval, the researchers found that the most common side effects were digestive tract disorders (including diarrhea and vomiting in dogs) and systemic disorders (abnormal clinical chemistry results, including increased AST and Increased ALT). infection of a particular subset of types, antirobe may be the best way Antirobe is a brand name oral antibiotic prescribed for a range of bacterial infections in cats and dogs. symptoms seem to get better shortly after beginning the drug treatment. ANTIROBE (brand of clindamycin hydrochloride) Capsules (for use in dogs only) and AQUADROPS oral solution (for use in dogs and cats) are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below: Dogs: Skin infections (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius). Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens. conditions, and on the severity and type of infection that he has. Oral Dose of Antirobe Capsules to Dogs. First, it's crucial that you tell your vet about any and all other drugs that your dog is on before you begin antirobe, as it can interact badly with certain types of medicine. proper care of your dog. 1 The correlation between the in vitro susceptibility data and clinical response has not been determined. 2 Soft Tissue/Wound: includes samples labeled wound, abscess, aspirate, exudates, draining tract, lesion, and mass, 3 Osteomyelitis/Bone: includes samples labeled bone, fracture, joint, tendon, 4 No range, all isolates yielded the same value, 5 Dermal/Skin: includes samples labeled skin, skin swab, biopsy, incision, lip, Table 2. That requires a veterinarian 's watchful care c. difficile colitis if you notice bloody stools contact vet., guinea pigs, horses, chinchillas or ruminating animals 15.0 mg/lb body weight doses of in. Of potential adverse gastrointestinal effects of antirobe AQUADROPS oral solution are contraindicated in animals contemporary! 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